Dr. Natalia Tretyakova Receives a Grant from the National Institutes of Health

Dr. Tretyakova has been awarded a grant of $342,947 from the National Institutes of Health for her project, "DNA Cross-Linking By Diepoxybutane." The objective of this project is to identify specific DNA lesions responsible for the genotoxic effects of DEB (1,2,3,4-diepoxybutane),  an intermediate produced by the metabolic activation of BD (1,3-butadiene), a known human carcinogen produced industrially and found in automobile exhaust and cigarette smoke.  Dr. Tretyakova and colleagues hope to afford new insights into the mechanisms of BD's mutagenicity and cytotoxicity, reducing the uncertainty in cancer risk assessment for human exposure to BD.