Medicinal Chemistry Faculty Awarded Grant Funding

Congratulations to faculty members who were recently awarded grants for their ongoing research!:

• Dr. Sunil David received an award of $300K from the National Institute of Allergy and Infectious Diseases to support additional studies related to his ongoing work on vaccines for the Zika virus.

• Dr. Mark Distefano, along with Dr. Ling Li, received a $1.875M National Institutes of Health award for their project, "Dysregulation of Protein Prenylation in the Pathogenesis of Alzheimer's Disease."

• Dr. Natalia Tretyakova received a $1,581,939 National Institutes of Health grant for her project, "DNA Cross-Linking By Diepoxybutane."

Dr. Peter Dosa Receives a Promotion

Congratulations to Dr. Peter Dosa who was promoted to Affiliate Research Associate Professor!

Dr. Natalia Tretyakova Receives a Grant from the National Institutes of Health

Dr. Tretyakova has been awarded a grant of $342,947 from the National Institutes of Health for her project, "DNA Cross-Linking By Diepoxybutane." The objective of this project is to identify specific DNA lesions responsible for the genotoxic effects of DEB (1,2,3,4-diepoxybutane),  an intermediate produced by the metabolic activation of BD (1,3-butadiene), a known human carcinogen produced industrially and found in automobile exhaust and cigarette smoke.  Dr. Tretyakova and colleagues hope to afford new insights into the mechanisms of BD's mutagenicity and cytotoxicity, reducing the uncertainty in cancer risk assessment for human exposure to BD.